Antagonism of the complement component C4 by flavivirus nonstructural protein NS1.

Avirutnan, Panisadee; Fuchs, Anja; Hauhart, Richard E; Somnuke, Pawit; Youn, Soonjeon; Diamond, Michael S; Atkinson, John P

Avirutnan, Panisadee; Fuchs, Anja; Hauhart, Richard E; Somnuke, Pawit; Youn, Soonjeon; Diamond, Michael S; Atkinson, John P.

Affiliation

Avirutnan P; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

J Exp Med ; 207(4): 793-806, 2010 Apr 12.

Article in En | MEDLINE | ID: mdl-20308361

Subject(s)

Complement C4/antagonists & inhibitors; Viral Nonstructural Proteins/metabolism; Animals; Biocatalysis/drug effects; CHO Cells; Complement C1/metabolism; Complement C1 Inhibitor Protein/metabolism; Complement C1s/agonists; Complement C1s/antagonists & inhibitors; Complement C1s/metabolism; Complement C3-C5 Convertases/metabolism; Complement C3b/metabolism; Complement C4/metabolism; Complement C4b/metabolism; Complement Factor I/metabolism; Complement Hemolytic Activity Assay; Complement Pathway, Classical/drug effects; Complement Pathway, Classical/immunology; Complement Pathway, Mannose-Binding Lectin/drug effects; Complement Pathway, Mannose-Binding Lectin/immunology; Cricetinae; Cricetulus; Dengue Virus/immunology; Enzyme Precursors/metabolism; Guinea Pigs; Humans; Kinetics; Neutralization Tests; Protein Binding/immunology; Viral Nonstructural Proteins/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Complement C4 / Viral Nonstructural Proteins Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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