Multiple RNA surveillance mechanisms cooperate to reduce the amount of nonfunctional Ig kappa transcripts.

Chemin, Guillaume; Tinguely, Aurélien; Sirac, Christophe; Lechouane, Fabien; Duchez, Sophie; Cogné, Michel; Delpy, Laurent

Chemin, Guillaume; Tinguely, Aurélien; Sirac, Christophe; Lechouane, Fabien; Duchez, Sophie; Cogné, Michel; Delpy, Laurent.

Affiliation

Chemin G; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6101, Université de Limoges, Limoges, France.

J Immunol ; 184(9): 5009-17, 2010 May 01.

Article in En | MEDLINE | ID: mdl-20357261

Subject(s)

Down-Regulation/genetics; Down-Regulation/immunology; Gene Rearrangement, B-Lymphocyte, Light Chain/immunology; Immunoglobulin kappa-Chains/genetics; RNA Splicing/immunology; RNA, Messenger/antagonists & inhibitors; Recombination, Genetic/immunology; Transcription, Genetic/immunology; Alleles; Animals; Cell Differentiation/genetics; Cell Differentiation/immunology; Cell Line, Tumor; Codon, Nonsense/antagonists & inhibitors; Codon, Nonsense/genetics; Codon, Nonsense/physiology; Codon, Terminator/antagonists & inhibitors; Codon, Terminator/genetics; Codon, Terminator/physiology; Frameshift Mutation/immunology; Immunoglobulin kappa-Chains/physiology; Mice; Plasma Cells/cytology; Plasma Cells/immunology; Plasma Cells/metabolism; RNA, Messenger/physiology; Stem Cells/cytology; Stem Cells/immunology; Stem Cells/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombination, Genetic / Transcription, Genetic / RNA, Messenger / Gene Rearrangement, B-Lymphocyte, Light Chain / Down-Regulation / RNA Splicing / Immunoglobulin kappa-Chains Type of study: Screening_studies Limits: Animals Language: En Journal: J Immunol Year: 2010 Document type: Article Affiliation country: France

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