Physicochemical parameters affecting liposomal bisphosphonates bioactivity for restenosis therapy: internalization, cell inhibition, activation of cytokines and complement, and mechanism of cell death.

Epstein-Barash, Hila; Gutman, Dikla; Markovsky, Ela; Mishan-Eisenberg, Galit; Koroukhov, Nickolay; Szebeni, Janos; Golomb, Gershon

Epstein-Barash, Hila; Gutman, Dikla; Markovsky, Ela; Mishan-Eisenberg, Galit; Koroukhov, Nickolay; Szebeni, Janos; Golomb, Gershon.

Affiliation

Epstein-Barash H; School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

J Control Release ; 146(2): 182-95, 2010 Sep 01.

Article in En | MEDLINE | ID: mdl-20359513

Subject(s)

Complement Activation/drug effects; Coronary Restenosis/drug therapy; Cytokines/immunology; Diphosphonates/administration & dosage; Diphosphonates/therapeutic use; Liposomes/chemistry; Animals; Cell Death/drug effects; Cell Line; Cells, Cultured; Coronary Restenosis/immunology; Diphosphonates/immunology; Diphosphonates/pharmacology; Humans; Liposomes/immunology; Male; Mice; Monocytes/cytology; Monocytes/drug effects; Rabbits; Rats

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Complement Activation / Coronary Restenosis / Diphosphonates / Liposomes Limits: Animals / Humans / Male Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2010 Document type: Article Affiliation country: Israel Country of publication: Netherlands

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