Inhibition of macrophage migration inhibitory factor ameliorates ocular Pseudomonas aeruginosa-induced keratitis.

Gadjeva, Mihaela; Nagashima, Jill; Zaidi, Tanweer; Mitchell, Robert A; Pier, Gerald B

Gadjeva, Mihaela; Nagashima, Jill; Zaidi, Tanweer; Mitchell, Robert A; Pier, Gerald B.

Affiliation

Gadjeva M; Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. mgadjeva@rics.bwh.harvard.edu

PLoS Pathog ; 6(3): e1000826, 2010 Mar 26.

Article in En | MEDLINE | ID: mdl-20361053

Subject(s)

Intramolecular Oxidoreductases/antagonists & inhibitors; Keratitis; Macrophage Migration-Inhibitory Factors/antagonists & inhibitors; Pseudomonas Infections; Pseudomonas aeruginosa/immunology; Pyrimidines/pharmacology; Animals; Disease Models, Animal; Epithelium, Corneal/immunology; Epithelium, Corneal/microbiology; Epithelium, Corneal/pathology; Female; Intramolecular Oxidoreductases/genetics; Intramolecular Oxidoreductases/immunology; Keratitis/drug therapy; Keratitis/immunology; Keratitis/microbiology; Macrophage Migration-Inhibitory Factors/genetics; Macrophage Migration-Inhibitory Factors/immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pseudomonas Infections/drug therapy; Pseudomonas Infections/immunology; Pseudomonas Infections/pathology; RNA, Small Interfering

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pseudomonas aeruginosa / Pseudomonas Infections / Pyrimidines / Macrophage Migration-Inhibitory Factors / Intramolecular Oxidoreductases / Keratitis Type of study: Prognostic_studies Limits: Animals Language: En Journal: PLoS Pathog Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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