Development and optimization of a cell-based neutralizing antibody assay using a sample pre-treatment step to eliminate serum interference.

McCutcheon, Krista M; Quarmby, Valerie; Song, An

McCutcheon, Krista M; Quarmby, Valerie; Song, An.

Affiliation

McCutcheon KM; Antibody Engineering, Genentech, South San Francisco, CA 94080, USA. krista@gene.com

J Immunol Methods ; 358(1-2): 35-45, 2010 Jun 30.

Article in En | MEDLINE | ID: mdl-20361968

Subject(s)

Antibodies, Neutralizing/analysis; Antibodies, Neutralizing/immunology; Artifacts; Cytotoxicity Tests, Immunologic/methods; Immunoassay/methods; Serum/chemistry; Serum/immunology; Animals; Antibodies, Monoclonal/immunology; Arthritis, Rheumatoid/immunology; Autoimmune Diseases/immunology; Cell Line, Tumor; Complement Pathway, Classical/immunology; Cross Reactions/immunology; Goats/immunology; Humans; Immunoglobulin G/immunology; Macaca fascicularis/immunology; Reproducibility of Results

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytotoxicity Tests, Immunologic / Immunoassay / Artifacts / Serum / Antibodies, Neutralizing Limits: Animals / Humans Language: En Journal: J Immunol Methods Year: 2010 Document type: Article Affiliation country: United States Country of publication: Netherlands

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