The pathogenesis of murine coronavirus infection of the central nervous system.
Crit Rev Immunol
; 30(2): 119-30, 2010.
Article
in En
| MEDLINE
| ID: mdl-20370625
Mouse hepatitis virus (MHV) is a positive-strand RNA virus that causes an acute encephalomyelitis that later resolves into a chronic fulminating demyelinating disease. Cytokine production, chemokine secretion, and immune cell infiltration into the central nervous system are critical to control viral replication during acute infection. Despite potent antiviral T-lymphocyte activity, sterile immunity is not achieved, and MHV chronically persists within oligodendrocytes. Continued infiltration and activation of the immune system, a result of the lingering viral antigen and RNA within oligodendrocytes, lead directly to the development of an immune-mediated demyelination that bears remarkable similarities, both clinically and histologically, to the human demyelinating disease multiple sclerosis. MHV offers a unique model system for studying host defense during acute viral infection and immune-mediated demyelination during chronic infection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coronavirus Infections
/
Murine hepatitis virus
/
Central Nervous System Viral Diseases
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Crit Rev Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2010
Document type:
Article
Affiliation country:
United States
Country of publication:
United States