Brain metabolic correlates of decision making in amnestic mild cognitive impairment.
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn
; 17(4): 492-504, 2010.
Article
in En
| MEDLINE
| ID: mdl-20373179
ABSTRACT
Persons with amnestic mild cognitive impairment (MCI) have subtle impairments in medical decision-making capacity (MDC). We examined the relationship between proton magnetic resonance spectroscopy (MRS) and MDC in MCI. Twenty-nine MCI patients and 42 controls underwent MRS to obtain ratios of N-acetylaspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr, and myo-Inositol (mI)/Cr of the posterior cingulate. They also completed the Capacity to Consent to Treatment Instrument (CCTI), a vignette-based instrument measuring decisional standards of expressing choice, appreciating consequences of choice, providing rational reasons for choice, and understanding treatment choices. Patients showed abnormal MRS ratios of mI/Cr and Cho/Cr compared to controls, and impairments on the CCTI understanding and reasoning Standards. Performance on the reasoning standard of the CCTI was correlated with NAA/Cr (r = .46, p < .05). The relationship of NAA/Cr with decision-making suggests a role for posterior cortical neuronal functioning in performance of complex IADLs in MCI.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Health Behavior
/
Cognition Disorders
/
Decision Making
/
Amnesia
Type of study:
Guideline
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn
Journal subject:
PSICOLOGIA
Year:
2010
Document type:
Article
Affiliation country:
United States