POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature.

Fortier, J M; Payton, J E; Cahan, P; Ley, T J; Walter, M J; Graubert, T A

Fortier, J M; Payton, J E; Cahan, P; Ley, T J; Walter, M J; Graubert, T A.

Affiliation

Fortier JM; Department of Internal Medicine, Division of Oncology, Stem Cell Biology Section, Washington University, St Louis, MO 63110, USA.

Leukemia ; 24(5): 950-7, 2010 May.

Article in En | MEDLINE | ID: mdl-20376082

Subject(s)

Chromosomes, Human, Pair 21/genetics; Chromosomes, Human, Pair 8/genetics; Gene Expression Profiling; Leukemia, Myeloid, Acute/genetics; Transcription Factor Brn-3A/genetics; Transcription Factor Brn-3A/physiology; Translocation, Genetic/genetics; Animals; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Bone Marrow Cells/metabolism; Bone Marrow Cells/pathology; Core Binding Factor Alpha 2 Subunit/genetics; Fetus/metabolism; Humans; Leukemia, Myeloid, Acute/metabolism; Leukemia, Myeloid, Acute/pathology; Liver/metabolism; Liver/pathology; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Oncogene Proteins, Fusion/genetics; RNA, Messenger/genetics; RNA, Messenger/metabolism; RUNX1 Translocation Partner 1 Protein; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor Brn-3A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Translocation, Genetic / Chromosomes, Human, Pair 8 / Chromosomes, Human, Pair 21 / Leukemia, Myeloid, Acute / Gene Expression Profiling / Transcription Factor Brn-3A Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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