Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.
Bioorg Med Chem Lett
; 20(9): 2809-12, 2010 May 01.
Article
in En
| MEDLINE
| ID: mdl-20378347
ABSTRACT
A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)-S-21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Piperazines
/
Thiophenes
/
Norepinephrine
/
Neurotransmitter Uptake Inhibitors
/
Ethylamines
Limits:
Animals
/
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2010
Document type:
Article
Affiliation country:
United States