Roasted licorice extracts dampen high glucose-induced mesangial hyperplasia and matrix deposition through blocking Akt activation and TGF-beta signaling.

Li, J; Lee, Y S; Choi, J-S; Sung, H-Y; Kim, J-K; Lim, S S; Kang, Y-H

Li, J; Lee, Y S; Choi, J-S; Sung, H-Y; Kim, J-K; Lim, S S; Kang, Y-H.

Affiliation

Li J; Department of Food and Nutrition and Korean Institute of Nutrition, Hallym University, Chuncheon, Kangwon-do 200-702, South Korea.

Phytomedicine ; 17(10): 800-10, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20382513

Subject(s)

Extracellular Matrix; Glomerular Mesangium/drug effects; Glucose/pharmacology; Glycyrrhiza/chemistry; Plant Extracts/pharmacology; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/drug effects; Transforming Growth Factor beta/metabolism; Base Sequence; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; DNA Primers; Enzyme Activation; Glomerular Mesangium/enzymology; Glomerular Mesangium/pathology; Humans; Hyperplasia; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Signal Transduction / Transforming Growth Factor beta / Proto-Oncogene Proteins c-akt / Extracellular Matrix / Glomerular Mesangium / Glucose / Glycyrrhiza Limits: Humans Language: En Journal: Phytomedicine Journal subject: TERAPIAS COMPLEMENTARES Year: 2010 Document type: Article Affiliation country: South Korea Country of publication: Germany

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