Pharmacokinetics of multiple-dose darunavir in combination with low-dose ritonavir in individuals with mild-to-moderate hepatic impairment.

Sekar, Vanitha; Spinosa-Guzman, Sabrina; De Paepe, Els; Stevens, Tanja; Tomaka, Frank; De Pauw, Martine; Hoetelmans, Richard M W

Sekar, Vanitha; Spinosa-Guzman, Sabrina; De Paepe, Els; Stevens, Tanja; Tomaka, Frank; De Pauw, Martine; Hoetelmans, Richard M W.

Affiliation

Sekar V; Tibotec Inc., Yardley, Pennsylvania, USA. vsekar@tibus.jnj.com

Clin Pharmacokinet ; 49(5): 343-50, 2010 May.

Article in En | MEDLINE | ID: mdl-20384396

Subject(s)

Liver Diseases/drug therapy; Liver Diseases/metabolism; Ritonavir/administration & dosage; Ritonavir/pharmacokinetics; Sulfonamides/administration & dosage; Sulfonamides/pharmacokinetics; Adult; Darunavir; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections/drug therapy; HIV Infections/metabolism; HIV Protease Inhibitors/administration & dosage; HIV Protease Inhibitors/blood; HIV Protease Inhibitors/pharmacokinetics; Humans; Male; Middle Aged; Ritonavir/blood; Sulfonamides/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Ritonavir / Liver Diseases Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Clin Pharmacokinet Year: 2010 Document type: Article Affiliation country: United States Country of publication: Switzerland

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