Inhibition of glutamate/glutamine cycle in vivo results in decreased benzodiazepine binding and differentially regulated GABAergic subunit expression in the rat brain.

Cremer, Christian M; Bidmon, Hans-Jürgen; Görg, Boris; Palomero-Gallagher, Nicola; Escobar, Jennifer Lopez; Speckmann, Erwin-Josef; Zilles, Karl

Cremer, Christian M; Bidmon, Hans-Jürgen; Görg, Boris; Palomero-Gallagher, Nicola; Escobar, Jennifer Lopez; Speckmann, Erwin-Josef; Zilles, Karl.

Affiliation

Cremer CM; Institute of Neuroscience and Medicine (INM-2), Research Center Jülich, Jülich, Germany. c.cremer@fz-juelich.de

Epilepsia ; 51(8): 1446-55, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20384720

Subject(s)

Benzodiazepines/metabolism; Brain/metabolism; Glutamic Acid/metabolism; Glutamine/metabolism; Receptors, GABA/metabolism; Animals; Autoradiography/methods; Binding Sites/drug effects; Brain/anatomy & histology; Brain/drug effects; Drug Interactions; Enzyme Inhibitors/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Glutamate-Ammonia Ligase/metabolism; Male; Methionine Sulfoximine/pharmacology; Protein Binding/drug effects; Protein Subunits/genetics; Protein Subunits/metabolism; RNA, Messenger/metabolism; Rats; Rats, Wistar; Receptors, GABA/genetics; Time Factors; Tritium/metabolism

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzodiazepines / Brain / Receptors, GABA / Glutamic Acid / Glutamine Type of study: Prognostic_studies Limits: Animals Language: En Journal: Epilepsia Year: 2010 Document type: Article Affiliation country: Germany

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google