Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity.

Bressi, Jerome C; de Jong, Ron; Wu, Yiqin; Jennings, Andy J; Brown, Jason W; O'Connell, Shawn; Tari, Leslie W; Skene, Robert J; Vu, Phong; Navre, Marc; Cao, Xiaodong; Gangloff, Anthony R

Bressi, Jerome C; de Jong, Ron; Wu, Yiqin; Jennings, Andy J; Brown, Jason W; O'Connell, Shawn; Tari, Leslie W; Skene, Robert J; Vu, Phong; Navre, Marc; Cao, Xiaodong; Gangloff, Anthony R.

Affiliation

Bressi JC; Takeda San Diego, San Diego, CA 92121, USA.

Bioorg Med Chem Lett ; 20(10): 3138-41, 2010 May 15.

Article in En | MEDLINE | ID: mdl-20392637

Subject(s)

Benzimidazoles/chemistry; Histone Deacetylase Inhibitors/chemistry; Histone Deacetylases/chemistry; Imidazoles/chemistry; Acetylation; Animals; Benzimidazoles/chemical synthesis; Benzimidazoles/pharmacology; Cell Line, Tumor; HL-60 Cells; Histone Deacetylase Inhibitors/chemical synthesis; Histone Deacetylase Inhibitors/pharmacology; Histone Deacetylases/metabolism; Humans; Imidazoles/chemical synthesis; Imidazoles/pharmacology; Mice; Mice, Nude; Structure-Activity Relationship; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Histone Deacetylase Inhibitors / Histone Deacetylases / Imidazoles Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States

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