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Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads.
Huang, Yifang; Strobel, Eric D; Ho, Chih Y; Reynolds, Charles H; Conway, Kelly A; Piesvaux, Jennifer A; Brenneman, Douglas E; Yohrling, George J; Moore Arnold, H; Rosenthal, Daniel; Alexander, Richard S; Tounge, Brett A; Mercken, Marc; Vandermeeren, Marc; Parker, Michael H; Reitz, Allen B; Baxter, Ellen W.
Affiliation
  • Huang Y; Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring House, PA 19477-0776, USA.
Bioorg Med Chem Lett ; 20(10): 3158-60, 2010 May 15.
Article in En | MEDLINE | ID: mdl-20399652

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Quinazolines / Aspartic Acid Endopeptidases / Macrocyclic Compounds / Amyloid Precursor Protein Secretases Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Quinazolines / Aspartic Acid Endopeptidases / Macrocyclic Compounds / Amyloid Precursor Protein Secretases Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom