Variation in the Cd3 zeta (Cd247) gene correlates with altered T cell activation and is associated with autoimmune diabetes.
J Immunol
; 184(10): 5537-44, 2010 May 15.
Article
in En
| MEDLINE
| ID: mdl-20400699
ABSTRACT
Tuning of TCR-mediated activation was demonstrated to be critical for lineage fate in T cell development, as well as in the control of autoimmunity. In this study, we identify a novel diabetes susceptibility gene, Idd28, in the NOD mouse and provide evidence that Cd3zeta (Cd247) constitutes a prime candidate gene for this locus. Moreover, we show that the allele of the Cd3zeta gene expressed in NOD and DBA/2 mouse strains confers lower levels of T cell activation compared with the allele expressed by C57BL/6 (B6), BALB/c, and C3H/HeJ mice. These results support a model in which the development of autoimmune diabetes is dependent on a TCR signal mediated by a less-efficient NOD allele of the Cd3zeta gene.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Variation
/
Lymphocyte Activation
/
T-Lymphocyte Subsets
/
CD3 Complex
/
Diabetes Mellitus, Type 1
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
J Immunol
Year:
2010
Document type:
Article
Affiliation country:
Sweden