Anxiety- and depressive-like responses and c-fos activity in preproenkephalin knockout mice: oversensitivity hypothesis of enkephalin deficit-induced posttraumatic stress disorder.

Kung, Jen-Chuang; Chen, Tsung-Chieh; Shyu, Bai-Chuang; Hsiao, Sigmund; Huang, Andrew Chih Wei

Kung, Jen-Chuang; Chen, Tsung-Chieh; Shyu, Bai-Chuang; Hsiao, Sigmund; Huang, Andrew Chih Wei.

Affiliation

Kung JC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.

J Biomed Sci ; 17: 29, 2010 Apr 21.

Article in En | MEDLINE | ID: mdl-20406487

Subject(s)

Anxiety/etiology; Depression/etiology; Enkephalins/deficiency; Protein Precursors/deficiency; Proto-Oncogene Proteins c-fos/metabolism; Stress Disorders, Post-Traumatic/etiology; Animals; Anxiety/metabolism; Anxiety/psychology; Avoidance Learning; Behavior, Animal; Brain/metabolism; Depression/metabolism; Depression/psychology; Disease Models, Animal; Electroshock; Enkephalins/genetics; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Protein Precursors/genetics; Stress Disorders, Post-Traumatic/metabolism; Stress Disorders, Post-Traumatic/psychology; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Protein Precursors / Stress Disorders, Post-Traumatic / Enkephalins / Proto-Oncogene Proteins c-fos / Depression Limits: Animals Language: En Journal: J Biomed Sci Journal subject: MEDICINA Year: 2010 Document type: Article Affiliation country: China Country of publication: United kingdom

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