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A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants.
Adiwijaya, Bambang S; Herrmann, Eva; Hare, Brian; Kieffer, Tara; Lin, Chao; Kwong, Ann D; Garg, Varun; Randle, John C R; Sarrazin, Christoph; Zeuzem, Stefan; Caron, Paul R.
Affiliation
  • Adiwijaya BS; Vertex Pharmaceuticals Incorporated, Cambridge, Massachusetts, United States of America. bambang_adiwijaya@vrtx.com
PLoS Comput Biol ; 6(4): e1000745, 2010 Apr 15.
Article in En | MEDLINE | ID: mdl-20419154
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Protease Inhibitors / Hepacivirus / Evolution, Molecular / Drug Resistance, Viral / Models, Biological Type of study: Prognostic_studies / Qualitative_research / Risk_factors_studies Limits: Humans Language: En Journal: PLoS Comput Biol Journal subject: BIOLOGIA / INFORMATICA MEDICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Protease Inhibitors / Hepacivirus / Evolution, Molecular / Drug Resistance, Viral / Models, Biological Type of study: Prognostic_studies / Qualitative_research / Risk_factors_studies Limits: Humans Language: En Journal: PLoS Comput Biol Journal subject: BIOLOGIA / INFORMATICA MEDICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States