Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury.
Brain Res
; 1340: 81-5, 2010 Jun 22.
Article
in En
| MEDLINE
| ID: mdl-20420812
ABSTRACT
Spinal cord injury (SCI) is a devastating condition. Melatonin supplementation has been shown to lessen SCI, but its use has been limited by its side effect profile. In this work, rats underwent a moderate-to-severe contussional SCI with either placebo or beta-methyl-6-chloromelatonin, 10mg/kg or 100mg/kg supplementation. The 10mg/kg supplementation demonstrated benefit; the 100mg/kg dosage was limited by toxicity. This is the first work to assess a melatonin analog in SCI.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Cord
/
Spinal Cord Injuries
/
Neuroprotective Agents
/
Melatonin
Limits:
Animals
Language:
En
Journal:
Brain Res
Year:
2010
Document type:
Article
Affiliation country:
United States