Plasma homocysteine level and 677C-->T mutation on the MTHFR gene in patients with venous thromboembolism.
Bratisl Lek Listy
; 111(2): 70-3, 2010.
Article
in En
| MEDLINE
| ID: mdl-20429317
ABSTRACT
BACKGROUND:
The aim of this study was to evaluate the role of plasma total homocysteine level and 677C-->T mutation on the methylenetetrahydrofolate reductase (MTHFR) gene in the development of venous thromboembolism.METHODS:
Thirty-six (18 male, 18 female and mean+SD; 48.3 +/- 15.5 years) patients with venous thromboembolism and 25 healthy adults (13 male, 12 female and mean +/- SD; 46.8 +/- 9.2 years) were included in the study. Fasting plasma total homocysteine level was determined by a high performance liquid chromatography. 677C-->T mutation on the MTHFR gene in peripheral blood was detected by Real Time-PCR method.RESULTS:
The level of plasma total homocysteine (18.5 +/- 10.6 micromol/L) was significantly higher in patients with venous thromboembolism than in the control group (11.0 +/- 4.7 micromol/L) (p=0.015). 677C-->T mutation on the MTHFR gene heterozygosity was higher in the patient group than in the control group [13 (36.1%) and 2 (8%) respectively] but this difference was not significant (p=0.07).CONCLUSION:
It is thought that a high plasma total homocysteine may cause venous thromboembolism (Tab. 2, Ref. 21). Full Text (Free, PDF) www.bmj.sk.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Point Mutation
/
Methylenetetrahydrofolate Reductase (NADPH2)
/
Venous Thromboembolism
/
Homocysteine
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Bratisl Lek Listy
Year:
2010
Document type:
Article
Affiliation country:
Turkey