Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity.

Galvagni, Federico; Pennacchini, Susanna; Salameh, Ahmad; Rocchigiani, Marina; Neri, Francesco; Orlandini, Maurizio; Petraglia, Felice; Gotta, Stefano; Sardone, Gian Luca; Matteucci, Giacomo; Terstappen, Georg C; Oliviero, Salvatore

Galvagni, Federico; Pennacchini, Susanna; Salameh, Ahmad; Rocchigiani, Marina; Neri, Francesco; Orlandini, Maurizio; Petraglia, Felice; Gotta, Stefano; Sardone, Gian Luca; Matteucci, Giacomo; Terstappen, Georg C; Oliviero, Salvatore.

Affiliation

Galvagni F; Dipartimento di Biologia Molecolare, Università degli Studi di Siena via Fiorentina 1-53100 Siena, Italy.

Circ Res ; 106(12): 1839-48, 2010 Jun 25.

Article in En | MEDLINE | ID: mdl-20431062

Subject(s)

Endothelium, Vascular/cytology; Endothelium, Vascular/metabolism; Extracellular Matrix/metabolism; Protein-Tyrosine Kinases/metabolism; Vascular Endothelial Growth Factor Receptor-3/metabolism; Animals; CSK Tyrosine-Protein Kinase; Cell Adhesion; Cell Line; Cells, Cultured; Collagen Type I/metabolism; Humans; MAP Kinase Kinase 4/metabolism; Mice; Mice, Knockout; Models, Animal; Phosphorylation; Proto-Oncogene Proteins c-crk/metabolism; Proto-Oncogene Proteins c-fyn/genetics; Proto-Oncogene Proteins c-fyn/metabolism; Proto-Oncogene Proteins c-yes/genetics; Proto-Oncogene Proteins c-yes/metabolism; Shc Signaling Adaptor Proteins/metabolism; src-Family Kinases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Endothelium, Vascular / Vascular Endothelial Growth Factor Receptor-3 / Extracellular Matrix Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Circ Res Year: 2010 Document type: Article Affiliation country: Italy Country of publication: United States

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