Nucleophilic substitution of oxazino-/oxazolino-/benzoxazin [3,2-b]indazoles: an effective route to 1H-indazolones.
Org Lett
; 12(11): 2524-7, 2010 Jun 04.
Article
in En
| MEDLINE
| ID: mdl-20438102
ABSTRACT
A variety of nucleophiles, thiolates, alkoxides, amines, iodide, and cyanide, react with oxazino-, oxazolino-, and benzoxazin[3,2-b]indazoles under microwave conditions to yield a diverse set of 2-substituted 1H-indazolones. The synthetic utility of these indazoles is further demonstrated by ANRORC (addition of the nucleophile, ring-opening, and ring closure) reactions to yield isomeric pyrazoloindazolones by a process wherein iodide acts first as a nucleophile and subsequently as a leaving group.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Indazoles
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2010
Document type:
Article
Affiliation country:
United States