Anthranilic acid replacements in a niacin receptor agonist.
Bioorg Med Chem Lett
; 20(11): 3426-30, 2010 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-20444602
ABSTRACT
Niacin is an effective drug for raising HDL cholesterol. However, niacin must be taken in large doses and significant side effects are often observed, including facial flushing, loss of glucose tolerance, and liver toxicity. An anthranilic acid was identified as an agonist of the niacin receptor. In order to improve efficacy and provide structural diversity, replacements for the anthranilic acid were investigated and several compounds with improved properties were identified.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Drug
/
Ortho-Aminobenzoates
/
Niacin
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2010
Document type:
Article
Affiliation country:
United States