The application of flow microreactors to the preparation of a family of casein kinase I inhibitors.
Org Biomol Chem
; 8(8): 1798-806, 2010 Apr 21.
Article
in En
| MEDLINE
| ID: mdl-20449482
ABSTRACT
In this article we demonstrate how a combination of enabling technologies such as flow synthesis, solid-supported reagents and scavenging resins utilised under fully automated software control can assist in typical medicinal chemistry programmes. In particular automated continuous flow methods have greatly assisted in the optimisation of reaction conditions and facilitated scale up operations involving hazardous chemical materials. Overall a collection of twenty diverse analogues of a casein kinase I inhibitor has been synthesised by changing three principle binding vectors.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridazines
/
Combinatorial Chemistry Techniques
/
Casein Kinase I
/
Protein Kinase Inhibitors
Type of study:
Evaluation_studies
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2010
Document type:
Article