Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells.

Mohan, Hema; Krumbholz, Markus; Sharma, Rakhi; Eisele, Sylvia; Junker, Andreas; Sixt, Michael; Newcombe, Jia; Wekerle, Hartmut; Hohlfeld, Reinhard; Lassmann, Hans; Meinl, Edgar

Mohan, Hema; Krumbholz, Markus; Sharma, Rakhi; Eisele, Sylvia; Junker, Andreas; Sixt, Michael; Newcombe, Jia; Wekerle, Hartmut; Hohlfeld, Reinhard; Lassmann, Hans; Meinl, Edgar.

Affiliation

Mohan H; Institute for Clinical Neuroimmunology, Ludwig Maximilians University, Munich, Germany.

Brain Pathol ; 20(5): 966-75, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20456365

Subject(s)

Biglycan/metabolism; Extracellular Matrix/pathology; Fibrillar Collagens/metabolism; Multiple Sclerosis/pathology; T-Lymphocytes/metabolism; Up-Regulation/physiology; Biglycan/genetics; Brain/metabolism; Brain/pathology; Cells, Cultured; Chemokines/metabolism; Collagen Type I/genetics; Collagen Type I/metabolism; Decorin/genetics; Decorin/metabolism; Enzyme-Linked Immunosorbent Assay/methods; Humans; Monocytes/metabolism; Monocytes/pathology; Proteoglycans/genetics; Proteoglycans/metabolism; RNA, Messenger/metabolism; T-Lymphocytes/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Up-Regulation / Fibrillar Collagens / Extracellular Matrix / Biglycan / Multiple Sclerosis Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Brain Pathol Journal subject: CEREBRO / PATOLOGIA Year: 2010 Document type: Article Affiliation country: Germany Country of publication: Switzerland

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