Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density.

Cawley, Niamh X; Yanik, Tulin; Woronowicz, Alicja; Chang, Weizhong; Marini, Joan C; Loh, Y Peng

Cawley, Niamh X; Yanik, Tulin; Woronowicz, Alicja; Chang, Weizhong; Marini, Joan C; Loh, Y Peng.

Affiliation

Cawley NX; Section on Cellular Neurobiology, Program on Developmental Neuroscience,Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 49 Convent Dr., Bethesda, MD 20892, USA.

Am J Physiol Endocrinol Metab ; 299(2): E189-97, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20460579

Subject(s)

Bone Density/physiology; Carboxypeptidase H/genetics; Carboxypeptidase H/physiology; Obesity/enzymology; Peptide Hormones/metabolism; Absorptiometry, Photon; Animals; Biomarkers; Bone Remodeling/physiology; Bone Resorption/genetics; Bone Resorption/metabolism; Calcium/blood; Enzyme-Linked Immunosorbent Assay; Female; Hypothalamus/metabolism; Male; Mice; Mice, Knockout; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neuropeptide Y/metabolism; Osteoclasts/metabolism; Osteoprotegerin/biosynthesis; Pituitary Gland, Intermediate/metabolism; Protein Array Analysis; RANK Ligand/biosynthesis; RANK Ligand/genetics; alpha-MSH/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Density / Peptide Hormones / Carboxypeptidase H / Obesity Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Endocrinol Metab Journal subject: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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