[An experimental research of neuroglobin expression changes and neural apoptosis after traumatic brain injury].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 26(1): 39-44, 2010 Feb.
Article
in Zh
| MEDLINE
| ID: mdl-20476562
ABSTRACT
OBJECTIVE:
To study the expression changes of neuroglobin in rats with the model of diffuse traumatic brain injury and explore the relationship between the neuroglobin and neuron apoptosis in traumatic brain injury.METHODS:
The diffuse traumatic brain injury of rats was induced by the Marmarou's 'weight-drop' device. And the immunohistochemical technique was used to detect the expression changes of neuroglobin and neuron apoptosis in rat brain at different time points post-injury.RESULTS:
The expression of neuroglobin increased twice and reached peaks at 2 hours and 72 hours post-injury respectively. And the increased expression of neuroglobin from 30 minutes to 1 hour post-injury and from 48 hours to 72 hours post-injury accompanied with the decreased expression ratio of Bax to Bcl-2.CONCLUSION:
The increased expression of neuroglobin in traumatic brain injury informed us that neuroglobin had anti-apoptosis action in post-injury neuron. It could protect the neuron from traumatic stress and secondary ischemia and hypoxia insults during ultra-early and acute stages.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Injuries
/
Globins
/
Apoptosis
/
Nerve Tissue Proteins
/
Neurons
Limits:
Animals
Language:
Zh
Journal:
Zhongguo Ying Yong Sheng Li Xue Za Zhi
Journal subject:
FISIOLOGIA
Year:
2010
Document type:
Article
Affiliation country:
China