Effect of pretreatment prednisolone on postendodontic pain: a double-blind parallel-randomized clinical trial.
J Endod
; 36(6): 978-81, 2010 Jun.
Article
in En
| MEDLINE
| ID: mdl-20478449
ABSTRACT
INTRODUCTION:
Effective management of endodontic pain represents a continuing challenge. This study evaluates the use of a preoperative, single oral dose of prednisolone for the prevention and control of postendodontic pain.METHODS:
Forty patients were randomly assigned to 2 groups, placebo and prednisolone (30 mg). The medications were administered 30 minutes before the start of standard endodontic treatment. Postoperative pain was assessed after 6, 12, and 24 hours by using a visual analogue scale.RESULTS:
The outcome showed that prednisolone resulted in a statistically significant reduction in postendodontic pain at 6, 12, and 24 hours (P < .0001). No side effects were reported for any of the medications used.CONCLUSIONS:
This study suggests that a preoperative, single oral dose of prednisolone substantially reduced postendodontic pain. Further studies are needed to evaluate the applicability of these findings to other clinical conditions, single- versus multiple-visit endodontic treatment, and drug regimens.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain, Postoperative
/
Premedication
/
Root Canal Therapy
/
Prednisolone
/
Analgesics, Non-Narcotic
/
Glucocorticoids
/
Anti-Inflammatory Agents
Type of study:
Clinical_trials
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Endod
Year:
2010
Document type:
Article
Affiliation country:
Iran