The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

Newton, Hayley J; Pearson, Jaclyn S; Badea, Luminita; Kelly, Michelle; Lucas, Mark; Holloway, Gavan; Wagstaff, Kylie M; Dunstone, Michelle A; Sloan, Joan; Whisstock, James C; Kaper, James B; Robins-Browne, Roy M; Jans, David A; Frankel, Gad; Phillips, Alan D; Coulson, Barbara S; Hartland, Elizabeth L

Newton, Hayley J; Pearson, Jaclyn S; Badea, Luminita; Kelly, Michelle; Lucas, Mark; Holloway, Gavan; Wagstaff, Kylie M; Dunstone, Michelle A; Sloan, Joan; Whisstock, James C; Kaper, James B; Robins-Browne, Roy M; Jans, David A; Frankel, Gad; Phillips, Alan D; Coulson, Barbara S; Hartland, Elizabeth L.

Affiliation

Newton HJ; Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.

PLoS Pathog ; 6(5): e1000898, 2010 May 13.

Article in En | MEDLINE | ID: mdl-20485572

Subject(s)

Escherichia coli O157/metabolism; Escherichia coli Proteins/metabolism; Shigella boydii/metabolism; Shigella flexneri/metabolism; Transcription Factor RelA/metabolism; Virulence Factors/metabolism; Active Transport, Cell Nucleus/physiology; Caco-2 Cells; Dysentery, Bacillary/immunology; Dysentery, Bacillary/metabolism; Dysentery, Bacillary/microbiology; Escherichia coli Infections/immunology; Escherichia coli Infections/metabolism; Escherichia coli Infections/microbiology; Escherichia coli O157/pathogenicity; HeLa Cells; Humans; I-kappa B Proteins/metabolism; Interleukin-8/genetics; Interleukin-8/metabolism; Intestinal Mucosa/immunology; Intestinal Mucosa/microbiology; NF-kappa B p50 Subunit/metabolism; Proto-Oncogene Proteins c-rel/metabolism; RNA, Messenger/metabolism; STAT1 Transcription Factor/metabolism; STAT2 Transcription Factor/metabolism; Shigella boydii/pathogenicity; Shigella flexneri/pathogenicity; Transcriptional Activation/physiology; Virulence

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Shigella boydii / Shigella flexneri / Escherichia coli O157 / Escherichia coli Proteins / Virulence Factors / Transcription Factor RelA Type of study: Prognostic_studies Limits: Humans Language: En Journal: PLoS Pathog Year: 2010 Document type: Article Affiliation country: Australia

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