Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1alpha) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats.

Benton, C R; Holloway, G P; Han, X-X; Yoshida, Y; Snook, L A; Lally, J; Glatz, J F C; Luiken, J J F P; Chabowski, A; Bonen, A

Benton, C R; Holloway, G P; Han, X-X; Yoshida, Y; Snook, L A; Lally, J; Glatz, J F C; Luiken, J J F P; Chabowski, A; Bonen, A.

Affiliation

Benton CR; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.

Diabetologia ; 53(9): 2008-19, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20490453

Subject(s)

Glucose/metabolism; Insulin/pharmacology; Muscle, Skeletal/metabolism; Obesity/metabolism; RNA-Binding Proteins/metabolism; Thinness/metabolism; Transcription Factors/metabolism; Animals; Blotting, Western; Fatty Acids/metabolism; Glucose Transporter Type 4/genetics; Glucose Transporter Type 4/metabolism; Lipid Metabolism/drug effects; Male; Muscle, Skeletal/drug effects; Oxidation-Reduction/drug effects; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation/drug effects; Proto-Oncogene Mas; RNA-Binding Proteins/genetics; Rats; Rats, Zucker; Signal Transduction/drug effects; Transcription Factors/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thinness / Transcription Factors / RNA-Binding Proteins / Muscle, Skeletal / Glucose / Insulin / Obesity Limits: Animals Language: En Journal: Diabetologia Year: 2010 Document type: Article Affiliation country: Canada Country of publication: Germany

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