A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy.

Christopher-Stine, Lisa; Casciola-Rosen, Livia A; Hong, Grace; Chung, Tae; Corse, Andrea M; Mammen, Andrew L

Christopher-Stine, Lisa; Casciola-Rosen, Livia A; Hong, Grace; Chung, Tae; Corse, Andrea M; Mammen, Andrew L.

Affiliation

Christopher-Stine L; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Arthritis Rheum ; 62(9): 2757-66, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20496415

Subject(s)

Autoantibodies/blood; Muscle Proteins/immunology; Muscle, Skeletal/pathology; Myositis/immunology; Myositis/pathology; Aged; Biomarkers/metabolism; Complement Membrane Attack Complex/metabolism; Female; Fluorescent Antibody Technique, Indirect; HeLa Cells; Histocompatibility Antigens Class I/metabolism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects; Immunoenzyme Techniques; Immunosuppressive Agents/therapeutic use; Male; Middle Aged; Muscle Fibers, Skeletal/drug effects; Muscle Fibers, Skeletal/metabolism; Muscle Fibers, Skeletal/pathology; Muscle, Skeletal/drug effects; Muscle, Skeletal/metabolism; Myositis/drug therapy; Necrosis; Platelet Endothelial Cell Adhesion Molecule-1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Muscle, Skeletal / Muscle Proteins / Myositis Type of study: Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Arthritis Rheum Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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