Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis.

Frey, Oliver; Meisel, Juliane; Hutloff, Andreas; Bonhagen, Kerstin; Bruns, Lisa; Kroczek, Richard A; Morawietz, Lars; Kamradt, Thomas

Frey, Oliver; Meisel, Juliane; Hutloff, Andreas; Bonhagen, Kerstin; Bruns, Lisa; Kroczek, Richard A; Morawietz, Lars; Kamradt, Thomas.

Affiliation

Frey O; Institut für Immunologie, Universitätsklinikum Jena, Jena 07743, Germany.

Ann Rheum Dis ; 69(8): 1495-501, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20498202

Subject(s)

Antibodies, Blocking/therapeutic use; Antigens, Differentiation, T-Lymphocyte/immunology; Arthritis, Experimental/prevention & control; Arthritis, Rheumatoid/prevention & control; T-Lymphocyte Subsets/immunology; T-Lymphocytes, Helper-Inducer/immunology; Animals; Arthritis, Experimental/immunology; Arthritis, Rheumatoid/immunology; Autoimmune Diseases/immunology; Autoimmune Diseases/prevention & control; Cell Differentiation/immunology; Cytokines/biosynthesis; Glucose-6-Phosphate/immunology; Immunoglobulins/biosynthesis; Inducible T-Cell Co-Stimulator Ligand; Inducible T-Cell Co-Stimulator Protein; Interleukin-17/analysis; Ligands; Lymph Nodes/immunology; Lymphocyte Activation/immunology; Lymphocyte Count; Mice; Mice, Inbred DBA; Proteins/immunology; Th1 Cells/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Arthritis, Rheumatoid / Antigens, Differentiation, T-Lymphocyte / T-Lymphocyte Subsets / T-Lymphocytes, Helper-Inducer / Antibodies, Blocking Limits: Animals Language: En Journal: Ann Rheum Dis Year: 2010 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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