Glucocerebrosidase deficiency dramatically impairs human bone marrow haematopoiesis in an in vitro model of Gaucher disease.

Berger, Juliette; Lecourt, Séverine; Vanneaux, Valérie; Rapatel, Chantal; Boisgard, Stéphane; Caillaud, Catherine; Boiret-Dupré, Nathalie; Chomienne, Christine; Marolleau, Jean-Pierre; Larghero, Jérôme; Berger, Marc G

Berger, Juliette; Lecourt, Séverine; Vanneaux, Valérie; Rapatel, Chantal; Boisgard, Stéphane; Caillaud, Catherine; Boiret-Dupré, Nathalie; Chomienne, Christine; Marolleau, Jean-Pierre; Larghero, Jérôme; Berger, Marc G.

Affiliation

Berger J; Hématologie Biologique, CHU Estaing, 1 place L. Aubrac, 63003 Clermont-Ferrand Cedex 1, France.

Br J Haematol ; 150(1): 93-101, 2010 Jul.

Article in En | MEDLINE | ID: mdl-20507316

Subject(s)

Gaucher Disease/enzymology; Glucosylceramidase/deficiency; Hematopoiesis/physiology; Bone Marrow Cells/enzymology; Cell Proliferation; Cells, Cultured; Colony-Forming Units Assay; Enzyme Inhibitors/pharmacology; Flow Cytometry/methods; Gaucher Disease/physiopathology; Glucosylceramidase/antagonists & inhibitors; Glucosylceramidase/blood; Hematopoiesis/drug effects; Hematopoietic Stem Cells/pathology; Humans; Inositol/analogs & derivatives; Inositol/pharmacology; Models, Biological; Tissue Culture Techniques

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gaucher Disease / Glucosylceramidase / Hematopoiesis Limits: Humans Language: En Journal: Br J Haematol Year: 2010 Document type: Article Affiliation country: France

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google