Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact.

Walker, Corey T; Marky, Andrew H; Petraglia, Anthony L; Ali, Tracy; Chow, Nienwen; Zlokovic, Berislav V

Walker, Corey T; Marky, Andrew H; Petraglia, Anthony L; Ali, Tracy; Chow, Nienwen; Zlokovic, Berislav V.

Affiliation

Walker CT; Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center, Arthur Kornberg Medical Research Building, 601 Elmwood Ave, Box 670, Rochester, New York 14642, USA.

Brain Res ; 1347: 125-31, 2010 Aug 06.

Article in En | MEDLINE | ID: mdl-20513369

Subject(s)

Anticoagulants/pharmacology; Anticoagulants/therapeutic use; Hemorrhage/drug therapy; Neuroprotective Agents/therapeutic use; Protein Kinase C/metabolism; Recovery of Function/drug effects; Animals; Anticoagulants/metabolism; Behavior, Animal; Brain Injuries/complications; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Hemorrhage/etiology; Mice; Mice, Inbred C57BL; Motor Activity/drug effects; Motor Activity/physiology; Neuroprotective Agents/pharmacology; Protein Kinase C/genetics; Psychomotor Performance/drug effects; Recombinant Proteins/pharmacology; Recombinant Proteins/therapeutic use; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase C / Neuroprotective Agents / Recovery of Function / Hemorrhage / Anticoagulants Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Brain Res Year: 2010 Document type: Article Affiliation country: United States Country of publication: Netherlands

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