FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.

Deng, Han-Xiang; Zhai, Hong; Bigio, Eileen H; Yan, Jianhua; Fecto, Faisal; Ajroud, Kaouther; Mishra, Manjari; Ajroud-Driss, Senda; Heller, Scott; Sufit, Robert; Siddique, Nailah; Mugnaini, Enrico; Siddique, Teepu

Deng, Han-Xiang; Zhai, Hong; Bigio, Eileen H; Yan, Jianhua; Fecto, Faisal; Ajroud, Kaouther; Mishra, Manjari; Ajroud-Driss, Senda; Heller, Scott; Sufit, Robert; Siddique, Nailah; Mugnaini, Enrico; Siddique, Teepu.

Affiliation

Deng HX; Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Chicago, IL 60611, USA. h-deng@northwestern.edu

Ann Neurol ; 67(6): 739-48, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20517935

Subject(s)

Amyotrophic Lateral Sclerosis/genetics; Brain/metabolism; Family Health; RNA-Binding Protein FUS/metabolism; Superoxide Dismutase/genetics; Superoxide Dismutase/metabolism; Amyotrophic Lateral Sclerosis/pathology; Brain/pathology; Cell Line, Transformed; DNA-Binding Proteins/metabolism; Female; Frontotemporal Lobar Degeneration/pathology; Humans; Inclusion Bodies/metabolism; Inclusion Bodies/pathology; Male; Microscopy, Confocal/methods; Mutation; RNA-Binding Protein FUS/genetics; Superoxide Dismutase-1; Transfection/methods; Ubiquitin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Superoxide Dismutase / Brain / Family Health / RNA-Binding Protein FUS / Amyotrophic Lateral Sclerosis Limits: Female / Humans / Male Language: En Journal: Ann Neurol Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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