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Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
McGuigan, Christopher; Gilles, Arnaud; Madela, Karolina; Aljarah, Mohamed; Holl, Sabrina; Jones, Sarah; Vernachio, John; Hutchins, Jeff; Ames, Brenda; Bryant, K Dawn; Gorovits, Elena; Ganguly, Babita; Hunley, Damound; Hall, Andrea; Kolykhalov, Alexander; Liu, Yule; Muhammad, Jerry; Raja, Nicholas; Walters, Robin; Wang, Jin; Chamberlain, Stanley; Henson, Geoffrey.
Affiliation
  • McGuigan C; Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, U.K. mcguigan@cardiff.ac.uk
J Med Chem ; 53(13): 4949-57, 2010 Jul 08.
Article in En | MEDLINE | ID: mdl-20527890
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Phosphoric Acids / Virus Replication / Hepatitis C / Hepacivirus / Amides / Guanosine Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: United kingdom Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Phosphoric Acids / Virus Replication / Hepatitis C / Hepacivirus / Amides / Guanosine Limits: Animals / Female / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: United kingdom Country of publication: United States