Structural determination Vitex cymosa Bertero active principle: Diastereoselective synthesis of (+/-)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one and its antinociceptive activity.
Bioorg Chem
; 38(5): 181-5, 2010 Oct.
Article
in En
| MEDLINE
| ID: mdl-20538314
ABSTRACT
The diastereoselective synthesis of (+/-)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one, as a mixture transcis (31), was accomplished using a protocol that combine the Prins cyclization and RuO(4) oxidation. The synthesis this lactone allowed the elucidation of the correct structure of the substance isolated from the barks of Vitex cymosa. The delta-lactones mixture showed significant antinociceptive properties in preliminary tests using the tail flick model assay.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain
/
Vitex
/
Analgesics
/
Lactones
Limits:
Animals
Language:
En
Journal:
Bioorg Chem
Year:
2010
Document type:
Article
Affiliation country:
Brazil
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA