Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue.

Pleeter, Perri; Lekostaj, Jacqueline K; Roepe, Paul D

Pleeter, Perri; Lekostaj, Jacqueline K; Roepe, Paul D.

Affiliation

Pleeter P; Department of Chemistry, Georgetown University, 37th and O Streets, Washington, DC 20057, USA.

Mol Biochem Parasitol ; 173(2): 158-61, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20546803

Subject(s)

Antimalarials/metabolism; Chloroquine/metabolism; Drug Resistance, Multiple; Multidrug Resistance-Associated Proteins/metabolism; Plasmodium falciparum/metabolism; Antimalarials/pharmacology; Binding Sites; Chloroquine/pharmacology; Mefloquine/metabolism; Multidrug Resistance-Associated Proteins/isolation & purification; Plasmodium falciparum/drug effects; Protein Binding; Quinine/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Chloroquine / Drug Resistance, Multiple / Multidrug Resistance-Associated Proteins / Antimalarials Language: En Journal: Mol Biochem Parasitol Year: 2010 Document type: Article Affiliation country: United States

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