Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers.

Roberts, Kathryn G; Smith, Amanda M; McDougall, Fiona; Carpenter, Helen; Horan, Martin; Neviani, Paolo; Powell, Jason A; Thomas, Daniel; Guthridge, Mark A; Perrotti, Danilo; Sim, Alistair T R; Ashman, Leonie K; Verrills, Nicole M

Roberts, Kathryn G; Smith, Amanda M; McDougall, Fiona; Carpenter, Helen; Horan, Martin; Neviani, Paolo; Powell, Jason A; Thomas, Daniel; Guthridge, Mark A; Perrotti, Danilo; Sim, Alistair T R; Ashman, Leonie K; Verrills, Nicole M.

Affiliation

Roberts KG; School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia.

Cancer Res ; 70(13): 5438-47, 2010 Jul 01.

Article in En | MEDLINE | ID: mdl-20551067

Subject(s)

Leukemia, Myeloid, Acute/enzymology; Protein Phosphatase 2/antagonists & inhibitors; Proto-Oncogene Proteins c-kit/metabolism; Aged; Animals; Apoptosis/drug effects; Cell Growth Processes/physiology; Cell Line, Tumor; Enzyme Activation; Female; Fingolimod Hydrochloride; Humans; Leukemia, Myeloid, Acute/drug therapy; Male; Mice; Mice, Inbred DBA; Phosphorylation; Propylene Glycols/pharmacology; Protein Phosphatase 2/biosynthesis; Protein Phosphatase 2/genetics; Protein Phosphatase 2/metabolism; Protein Subunits; Proto-Oncogene Proteins c-kit/genetics; Signal Transduction; Sphingosine/analogs & derivatives; Sphingosine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Proto-Oncogene Proteins c-kit / Protein Phosphatase 2 Limits: Aged / Animals / Female / Humans / Male Language: En Journal: Cancer Res Year: 2010 Document type: Article Affiliation country: Australia

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