Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus.

Sun, Xiangjie; Tse, Longping V; Ferguson, A Damon; Whittaker, Gary R

Sun, Xiangjie; Tse, Longping V; Ferguson, A Damon; Whittaker, Gary R.

Affiliation

Sun X; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.

J Virol ; 84(17): 8683-90, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20554779

Subject(s)

Hemagglutinin Glycoproteins, Influenza Virus/metabolism; Influenza A Virus, H1N1 Subtype/pathogenicity; Influenza, Human/virology; Protein Processing, Post-Translational; Amino Acid Sequence; Animals; Brain/virology; Cell Line; Female; Fibrinolysin/metabolism; Hemagglutinin Glycoproteins, Influenza Virus/chemistry; Hemagglutinin Glycoproteins, Influenza Virus/genetics; Humans; Influenza A Virus, H1N1 Subtype/chemistry; Influenza A Virus, H1N1 Subtype/genetics; Influenza A Virus, H1N1 Subtype/physiology; Influenza, Human/enzymology; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; Sequence Alignment; Virulence; Virus Replication

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Processing, Post-Translational / Hemagglutinin Glycoproteins, Influenza Virus / Influenza, Human / Influenza A Virus, H1N1 Subtype Limits: Animals / Female / Humans Language: En Journal: J Virol Year: 2010 Document type: Article Affiliation country: United States

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