In vitro performance assessment of new brushite-forming Zn- and ZnSr-substituted beta-TCP bone cements.
J Biomed Mater Res B Appl Biomater
; 94(2): 414-420, 2010 Aug.
Article
in En
| MEDLINE
| ID: mdl-20574977
ABSTRACT
The present study investigated the in vitro performance of brushite-forming Zn- and ZnSr-substituted beta-TCP bone cements in terms of wet mechanical strength and biological response. Quantitative phase analysis and structural refinement of the powdered samples were performed by X-ray powder diffraction and Rietveld refinement technique. Initial and final setting times of the cement pastes, measured using Gilmore needles technique, showed that ZnSrCPC sets faster than ZnCPC. The measured values of the wet strength after 48 h of immersion in PBS solution at 37 degrees C showed that ZnSrCPC cements are stronger than ZnCPC cements. Human osteosarcoma-derived MG63 cell line proved the nontoxicity of the cement powders, using the resazurin metabolic assay.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Cements
/
Materials Testing
/
Calcium Phosphates
Limits:
Humans
Language:
En
Journal:
J Biomed Mater Res B Appl Biomater
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2010
Document type:
Article
Affiliation country:
Portugal