ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

Xu, Baihua; Feng, Yan; Lv, Binhua; Xu, Ge; Zhang, Lili; Du, Jiyan; Peng, Kun; Xu, Min; Dong, Jiajia; Zhang, Wenbin; Zhang, Ting; Zhu, Liangcheng; Ding, Haifeng; Sheng, Zelin; Welihinda, Ajith; Seed, Brian; Chen, Yuanwei

Xu, Baihua; Feng, Yan; Lv, Binhua; Xu, Ge; Zhang, Lili; Du, Jiyan; Peng, Kun; Xu, Min; Dong, Jiajia; Zhang, Wenbin; Zhang, Ting; Zhu, Liangcheng; Ding, Haifeng; Sheng, Zelin; Welihinda, Ajith; Seed, Brian; Chen, Yuanwei.

Affiliation

Xu B; Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, Sichuan 610041, PR China. xubaihua2002@126.com

Bioorg Med Chem ; 18(12): 4422-32, 2010 Jun 15.

Article in En | MEDLINE | ID: mdl-20576578

Subject(s)

Glucosides/chemistry; Hypoglycemic Agents/chemistry; Sodium-Glucose Transporter 2 Inhibitors; Cell Line; Glucosides/chemical synthesis; Glucosides/pharmacology; Humans; Hypoglycemic Agents/chemical synthesis; Hypoglycemic Agents/pharmacology; Sodium-Glucose Transporter 1/antagonists & inhibitors; Sodium-Glucose Transporter 1/metabolism; Sodium-Glucose Transporter 2/metabolism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium-Glucose Transporter 2 Inhibitors / Glucosides / Hypoglycemic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Country of publication: United kingdom

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