An oxygen-consuming phantom simulating perfused tissue to explore oxygen dynamics and (19)F MRI oximetry.
MAGMA
; 23(4): 217-26, 2010 Sep.
Article
in En
| MEDLINE
| ID: mdl-20577778
ABSTRACT
OBJECTIVE:
This study presents a reproducible phantom which mimics oxygen-consuming tissue and can be used for the validation of (19)F MRI oximetry. MATERIALS ANDMETHODS:
The phantom consists of a haemodialysis filter of which the outer compartment is filled with a gelatin matrix containing viable yeast cells. Perfluorocarbon emulsions can be added to the gelatin matrix to simulate sequestered perfluorocarbons. A blood-substituting perfluorocarbon fluid is pumped through the lumen of the fibres in the filter. (19)F relaxometry MRI is performed with a fast 2D Look-Locker imaging sequence on a clinical 3T scanner.RESULTS:
Acute and perfusion-related hypoxia were simulated and imaged spatially and temporally using the phantom.CONCLUSIONS:
The presented experimental setup can be used to simulate oxygen consumption by somatic cells in vivo and for validating computational biophysical models of hypoxia, as measured with (19)F MRI oximetry.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxygen
/
Oxygen Consumption
/
Oximetry
/
Magnetic Resonance Imaging
/
Phantoms, Imaging
/
Fluorine
Type of study:
Prognostic_studies
Language:
En
Journal:
MAGMA
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2010
Document type:
Article
Affiliation country:
Belgium