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BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Clarke, Brian; Cutler, Leanne; Demont, Emmanuel; Dingwall, Colin; Dunsdon, Rachel; Hawkins, Julie; Howes, Colin; Hussain, Ishrut; Maile, Graham; Matico, Rosalie; Mosley, Julie; Naylor, Alan; O'Brien, Alistair; Redshaw, Sally; Rowland, Paul; Soleil, Virginie; Smith, Kathrine J; Sweitzer, Sharon; Theobald, Pam; Vesey, David; Walter, Daryl S; Wayne, Gareth.
Affiliation
  • Clarke B; Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline R&D, New Frontiers Science Park, Harlow, Essex, UK.
Bioorg Med Chem Lett ; 20(15): 4639-44, 2010 Aug 01.
Article in En | MEDLINE | ID: mdl-20579874
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Protease Inhibitors / Ethylamines / Amyloid Precursor Protein Secretases Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Protease Inhibitors / Ethylamines / Amyloid Precursor Protein Secretases Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom