Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor.

Kachhap, Sushant K; Rosmus, Nadine; Collis, Spencer J; Kortenhorst, Madeleine S Q; Wissing, Michel D; Hedayati, Mohammad; Shabbeer, Shabana; Mendonca, Janet; Deangelis, Justin; Marchionni, Luigi; Lin, Jianqing; Höti, Naseruddin; Nortier, Johan W R; DeWeese, Theodore L; Hammers, Hans; Carducci, Michael A

Kachhap, Sushant K; Rosmus, Nadine; Collis, Spencer J; Kortenhorst, Madeleine S Q; Wissing, Michel D; Hedayati, Mohammad; Shabbeer, Shabana; Mendonca, Janet; Deangelis, Justin; Marchionni, Luigi; Lin, Jianqing; Höti, Naseruddin; Nortier, Johan W R; DeWeese, Theodore L; Hammers, Hans; Carducci, Michael A.

Affiliation

Kachhap SK; Prostate Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. kachhsu@jhmi.edu

PLoS One ; 5(6): e11208, 2010 Jun 18.

Article in En | MEDLINE | ID: mdl-20585447

Subject(s)

DNA Repair/genetics; Down-Regulation/physiology; E2F1 Transcription Factor/physiology; Histone Deacetylases/metabolism; Prostatic Neoplasms/genetics; Recombination, Genetic; Cell Line, Tumor; Chromatin Immunoprecipitation; Comet Assay; DNA Damage; Fluorescent Antibody Technique; Humans; Male; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Prostatic Neoplasms/enzymology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Recombination, Genetic / Down-Regulation / DNA Repair / E2F1 Transcription Factor / Histone Deacetylases Limits: Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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