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Does surfactant type cause a differential proinflammatory response in preterm infants with respiratory distress syndrome?
Mercado, Vanessa V; Cristea, Ioana; Ali, Noorjahan; Pham, Chau Chau; Buescher, Elizabeth; Yang, Jean; Fisher, Joie; Maramreddy, Hima; Calo, Johanna; Strassberg, Sonya; Parton, Lance A.
Affiliation
  • Mercado VV; Maria Fareri Children's Hospital, New York Medical College, Valhalla, NY 10595, USA. vanessa_mercado@nymc.edu
Adv Ther ; 27(7): 476-82, 2010 Jul.
Article in En | MEDLINE | ID: mdl-20586001
INTRODUCTION: The objective of this study was to compare the pulmonary inflammatory response of premature infants with respiratory distress following instillation of one of two commonly available surfactant preparations. METHODS: This was a prospective, randomized investigation of preterm infants who were less than 30 weeks of gestational age, weighed less than 1 kg at birth, and who qualified to receive surfactant. Infants with multiple congenital anomalies or whose mothers were taking anti-inflammatory medications were ineligible. Tracheal aspirates (TAs) were collected on days 1, 3, 5, and 7 and airway cytokines from TAs were assayed for interleukin (IL)-8 and IL-6. RESULTS: Infants were evenly matched by gestation (26+/-2 days and 26+/-1 days [mean+/-SD], Surfactant A and B, respectively) and birth weight (730+/-141 g and 732+/-167 g). TA cytokine levels were not different between or within groups. Ventilator requirements and clinical outcomes were similar between the two groups. CONCLUSION: The postnatal airway inflammatory response observed in preterm infants is not altered by the instillation of either surfactant preparation.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Distress Syndrome, Newborn / Pulmonary Surfactants / Infant, Premature / Cytokines Type of study: Clinical_trials Limits: Female / Humans / Male / Newborn Language: En Journal: Adv Ther Journal subject: TERAPEUTICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Distress Syndrome, Newborn / Pulmonary Surfactants / Infant, Premature / Cytokines Type of study: Clinical_trials Limits: Female / Humans / Male / Newborn Language: En Journal: Adv Ther Journal subject: TERAPEUTICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States