Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry.

Kravitz, Alexxai V; Freeze, Benjamin S; Parker, Philip R L; Kay, Kenneth; Thwin, Myo T; Deisseroth, Karl; Kreitzer, Anatol C

Kravitz, Alexxai V; Freeze, Benjamin S; Parker, Philip R L; Kay, Kenneth; Thwin, Myo T; Deisseroth, Karl; Kreitzer, Anatol C.

Affiliation

Kravitz AV; Gladstone Institute of Neurological Disease, 1650 Owens St, San Francisco, California 94158, USA.

Nature ; 466(7306): 622-6, 2010 Jul 29.

Article in En | MEDLINE | ID: mdl-20613723

Subject(s)

Basal Ganglia/cytology; Basal Ganglia/physiopathology; Models, Neurological; Neural Pathways/physiopathology; Parkinson Disease/pathology; Parkinson Disease/physiopathology; Animals; Basal Ganglia/pathology; Basal Ganglia/physiology; Channelrhodopsins; Chromosomes, Artificial, Bacterial/genetics; Disease Models, Animal; Gait; Hypokinesia/complications; Hypokinesia/genetics; Hypokinesia/physiopathology; Integrases/genetics; Integrases/metabolism; Mice; Mice, Transgenic; Motor Activity/physiology; Neostriatum/cytology; Neostriatum/pathology; Neostriatum/physiology; Neostriatum/physiopathology; Neural Pathways/cytology; Neural Pathways/pathology; Neural Pathways/physiology; Neurons/cytology; Neurons/pathology; Neurons/physiology; Oxidopamine; Parkinson Disease/complications; Parkinson Disease/genetics; Psychomotor Performance; Receptors, Dopamine/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Basal Ganglia / Models, Neurological / Neural Pathways Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nature Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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