A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

Milyavsky, Michael; Gan, Olga I; Trottier, Magan; Komosa, Martin; Tabach, Ofer; Notta, Faiyaz; Lechman, Eric; Hermans, Karin G; Eppert, Kolja; Konovalova, Zhanna; Ornatsky, Olga; Domany, Eytan; Meyn, M Stephen; Dick, John E

Milyavsky, Michael; Gan, Olga I; Trottier, Magan; Komosa, Martin; Tabach, Ofer; Notta, Faiyaz; Lechman, Eric; Hermans, Karin G; Eppert, Kolja; Konovalova, Zhanna; Ornatsky, Olga; Domany, Eytan; Meyn, M Stephen; Dick, John E.

Affiliation

Milyavsky M; Department of Stem Cell and Developmental Biology, University of Toronto, Toronto, ON M5G 1L7, Canada.

Cell Stem Cell ; 7(2): 186-97, 2010 Aug 06.

Article in En | MEDLINE | ID: mdl-20619763

Subject(s)

Apoptosis; DNA Damage; Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/metabolism; Tumor Suppressor Protein p53/metabolism; Adaptor Proteins, Signal Transducing/metabolism; Animals; Apoptosis/radiation effects; Apoptosis Regulatory Proteins/metabolism; Cell Lineage/radiation effects; Cell Proliferation/radiation effects; Cell Survival/radiation effects; Cytoprotection/radiation effects; DNA Breaks, Double-Stranded/radiation effects; HeLa Cells; Hematopoietic Stem Cells/radiation effects; Humans; Mice; Myelopoiesis/radiation effects; Proto-Oncogene Proteins c-bcl-2/metabolism; Radiation, Ionizing; Recombination, Genetic/radiation effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Hematopoietic Stem Cells / Tumor Suppressor Protein p53 / Apoptosis Limits: Animals / Humans Language: En Journal: Cell Stem Cell Year: 2010 Document type: Article Affiliation country: Canada

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