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Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Guo, Liangqin; Ye, Zhixiong; Liu, Jian; He, Shuwen; Bakshi, Raman K; Sebhat, Iyassu K; Dobbelaar, Peter H; Hong, Qingmei; Jian, Tianying; Dellureficio, James P; Tsou, Nancy N; Ball, Richard G; Weinberg, David H; MacNeil, Tanya; Tang, Rui; Tamvakopoulos, Constantin; Peng, Qianping; Chen, Howard Y; Chen, Airu S; Martin, William J; MacIntyre, D Euan; Strack, Alison M; Fong, Tung M; Wyvratt, Matthew J; Nargund, Ravi P.
Affiliation
  • Guo L; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. liangqin_guo@merck.com
Bioorg Med Chem Lett ; 20(16): 4895-900, 2010 Aug 15.
Article in En | MEDLINE | ID: mdl-20621473
ABSTRACT
Design, synthesis, and SAR of a series of 3H-spiro[isobenzofuran-1,4'-piperidine] based compounds as potent, selective and orally bioavailable melanocortin subtype-4 receptor (MC4R) agonists are disclosed.
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Receptor, Melanocortin, Type 4 Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Receptor, Melanocortin, Type 4 Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States