The use of human hepatocytes to investigate drug metabolism and CYP enzyme induction.

Klieber, Sylvie; Torreilles, François; Guillou, François; Fabre, Gérard

Klieber, Sylvie; Torreilles, François; Guillou, François; Fabre, Gérard.

Affiliation

Klieber S; Discovery Metabolism and Pharmacokinetics Safety, Sanofi-Aventis Recherche, Montpellier, France.

Methods Mol Biol ; 640: 295-308, 2010.

Article in En | MEDLINE | ID: mdl-20645059

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Hepatocytes/enzymology; Pharmaceutical Preparations/metabolism; Cell Survival/drug effects; Cells, Cultured; Cryopreservation; Cytochrome P-450 Enzyme System/genetics; Enzyme Induction/drug effects; Gene Expression/drug effects; Hepatocytes/drug effects; Hepatocytes/metabolism; Humans; Models, Biological; RNA, Messenger/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Hepatocytes / Cytochrome P-450 Enzyme System Type of study: Prognostic_studies Limits: Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2010 Document type: Article Affiliation country: France Country of publication: United States

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