Development of inhalable nanocrystalline solid dispersion of tranilast for airway inflammatory diseases.

Onoue, Satomi; Aoki, Yosuke; Kawabata, Yohei; Matsui, Takuya; Yamamoto, Kiyoshi; Sato, Hideyuki; Yamauchi, Yukinori; Yamada, Shizuo

Onoue, Satomi; Aoki, Yosuke; Kawabata, Yohei; Matsui, Takuya; Yamamoto, Kiyoshi; Sato, Hideyuki; Yamauchi, Yukinori; Yamada, Shizuo.

Affiliation

Onoue S; Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan. onoue@u-shizuoka-ken.ac.jp

J Pharm Sci ; 100(2): 622-33, 2011 Feb.

Article in En | MEDLINE | ID: mdl-20653048

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/administration & dosage; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use; Nanoparticles/chemistry; Pulmonary Disease, Chronic Obstructive/drug therapy; ortho-Aminobenzoates/administration & dosage; ortho-Aminobenzoates/therapeutic use; Administration, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics; Asthma/drug therapy; Crystallization; Lung/drug effects; Lung/pathology; Male; Rats; Rats, Sprague-Dawley; Solubility; ortho-Aminobenzoates/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-Inflammatory Agents, Non-Steroidal / Pulmonary Disease, Chronic Obstructive / Nanoparticles / Ortho-Aminobenzoates Limits: Animals Language: En Journal: J Pharm Sci Year: 2011 Document type: Article Affiliation country: Japan

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